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Version: 17.06d (Release date: 2017-06-26)
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Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins (Code C67061)

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Terms & Properties

Preferred Name: Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins

Definition: A combination preparation of 1:1 mixture of two immunotoxins, HD37-dgA and RFB4-dgA, with potential antineoplastic activity. Both anti-CD19 IgG monoclonal antibody HD37 and anti-CD22 IgG monoclonal antibody RFB4 are attached to a single deglycosylated ricin A chain (dgA) via N-succinimidyl-oxycarbonyl-alpha-methyl-alpha-(2-pyridyldithio) toluene (SMPT) linker. CD19 and CD22 molecules are cell suface antigens present on the majority of B acute lymphoblastic leukemia cells. This combination agent is able to specifically recognize and bind to CD19 and CD22 expressing tumor cells, thereby targeting the delivery of the cytotoxic ricin A chain to leukemia cells expressing these antigens. Ricin A chain is toxic to ribosomal activity and protein synthesis, and inhibits cell growth.

Display Name: Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins

Label: Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins

NCI Thesaurus Code: C67061 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880271  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Combotox
Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins

External Source Codes: 
PDQ Closed Trial Search ID 538436
PDQ Open Trial Search ID 538436 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880271

Other Properties:
     Name Value (qualifiers indented underneath)
code C67061
Contributing_Source CTRP
Legacy_Concept_Name Deglycosylated_Ricin_A_Chain-Conjugated_Anti-CD19_Anti-CD22_Immunotoxins
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67061

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