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Version: 17.04d (Release date: 2017-04-24)
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Quinacrine Hydrochloride (Code C67059)

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Terms & Properties

Preferred Name: Quinacrine Hydrochloride

Definition: The dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.

Display Name: Quinacrine Hydrochloride

Label: Quinacrine Hydrochloride

NCI Thesaurus Code: C67059 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0282331  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine Dihydrochloride
Atabrine Dihydrochloride
Mepacrine Dihydrochloride
Quinacrine Dihydrochloride
Quinacrine Hydrochloride
QUINACRINE HYDROCHLORIDE
SN 390

External Source Codes: 
CAS Registry Number 6151-30-0 (see NLM ChemIDplus info)
FDA UNII Code G6242H2NAA
NSC Code 14229 (see NCI DTP info)
PDQ Closed Trial Search ID 531122
PDQ Open Trial Search ID 531122 (check for NCI PDQ open clinical trial info)
UMLS CUI C0282331

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H30ClN3O.2ClH.2H2O
code C67059
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Quinacrine_Dihydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67059

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