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Version: 17.06d (Release date: 2017-06-26)
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HSV-TK-Transduced Donor Lymphocytes (Code C67047)

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Terms & Properties

Preferred Name: HSV-TK-Transduced Donor Lymphocytes

Definition: A preparation of donor lymphocytes transduced with the suicide gene herpes simplex virus thymidine kinase (HSV-TK) with potential immunomodulating activity. Administration of HSV-TK-transduced lymphocytes after T cell-depleted allogeneic stem cell transplantation allows an early controllable immune reconstitution, which takes advantage of the antitumor effect of donor lymphocytes and helps to mitigate the risk of post-transplant opportunistic infection. To control graft-versus-host disease (GvHD) due to donor lymphocyte infusion, HSV-TK-transduced donor lymphocytes are selectively eliminated by administration of the antiviral agent ganciclovir. Ganciclovir, a prodrug, is readily phosphorylated by the suicide gene HSV-TK within HSV-TK-transduced lymphocytes to its monophosphate form and, subsequently, converted into its active triphosphate form, which specifically kills HSV-TK- transduced donor lymphocytes.

Display Name: HSV-TK-Transduced Donor Lymphocytes

Label: HSV-TK-Transduced Donor Lymphocytes

NCI Thesaurus Code: C67047 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1881029  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HSV-TK-Transduced Donor Lymphocytes
HSV-TK Engineered Donor Lymphocytes
HSVTK Retrovirally-transduced Donor T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 536528
PDQ Open Trial Search ID 536528 (check for NCI PDQ open clinical trial info)
UMLS CUI C1881029

Other Properties:
     Name Value (qualifiers indented underneath)
code C67047
Contributing_Source CTRP
Legacy_Concept_Name HSV-TK_Transduced_Donor_Lymphocytes
Semantic_Type Cell

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67047

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