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Version: 17.06d (Release date: 2017-06-26)
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Human Lactoferrin Peptide hLF1-11 (Code C67046)

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Terms & Properties

Preferred Name: Human Lactoferrin Peptide hLF1-11

Definition: A synthetic peptide corresponding to the first 11 N-terminal amino acids of human lactoferrin (hLF1-11) with potential antimicrobial activity. Human lactoferrin, a 692 amino acid glycoprotein belonging to the transferrin family of metal-binding proteins, can be found in milk and other secretory fluids as well as in polymorphonuclear cells and leukocytes. Human lactoferrin plays a role in the innate defense of mucosal surfaces and neutrophils. Although the exact mechanism through which this peptide exerts its effect has yet to be fully elucidated, hLF1-11 may seize iron, thereby limiting the availability of free iron for microorganisms in the body. hLF1-11 appears to be effective against a variety of bacteria and fungi, including the multidrug-resistant Acinetobacter baumannii, multidrug-resistant Staphylococcus aureus, and fluconazole-resistant Candida albicans strains.

Label: Human Lactoferrin Peptide hLF1-11

NCI Thesaurus Code: C67046 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1144139  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hLF(1-11)
Human Lactoferrin Peptide hLF1-11

External Source Codes: 
PDQ Closed Trial Search ID 537368
PDQ Open Trial Search ID 537368 (check for NCI PDQ open clinical trial info)
UMLS CUI C1144139

Other Properties:
     Name Value (qualifiers indented underneath)
code C67046
Legacy_Concept_Name Human_Lactoferrin_1-11_Peptide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67046

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