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Version: 17.06d (Release date: 2017-06-26)
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Daporinad (Code C67043)

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Terms & Properties

Preferred Name: Daporinad

Definition: A small molecule with potential antineoplastic and antiangiogenic activities. Daporinad binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell production of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis. The coenzyme NAD+ plays an essential role in cellular redox reactions, including the redox reaction linking the citric acid cycle and oxidative phosphorylation.

Label: Daporinad

NCI Thesaurus Code: C67043 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879518  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)prop-2-enamide
APO866
DAPORINAD
Daporinad
FK-866
K 22.175
NMPRTase Inhibitor APO866

External Source Codes: 
CAS Registry Number 658084-64-1 (see NLM ChemIDplus info)
FDA UNII Code V71TF6V9M7
PDQ Closed Trial Search ID 537396
PDQ Open Trial Search ID 537396 (check for NCI PDQ open clinical trial info)
UMLS CUI C1879518

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H29N3O2
code C67043
Contributing_Source FDA
Legacy_Concept_Name APO866
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67043

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