|MDR Modulator CBT-1 (Code C67042)|
|Terms & Properties|
Preferred Name: MDR Modulator CBT-1
Definition: A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors.
NCI-GLOSS Definition: A substance taken from plants that is being studied in the treatment of cancer. It may help drugs kill tumor cells that have become resistant to drugs. It is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.
Label: MDR Modulator CBT-1
NCI Metathesaurus Link: C0916470 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|MDR Modulator CBT-1|
|MDR modulator CBT-1|
External Source Codes:
|PDQ Closed Trial Search ID||538747|
|PDQ Open Trial Search ID||538747 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|