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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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MDR Modulator CBT-1 (Code C67042)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: MDR Modulator CBT-1

Definition: A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors.

NCI-GLOSS Definition: A substance taken from plants that is being studied in the treatment of cancer. It may help drugs kill tumor cells that have become resistant to drugs. It is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.

Label: MDR Modulator CBT-1

NCI Thesaurus Code: C67042 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0916470  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CBT-1
MDR Modulator CBT-1
MDR modulator CBT-1

External Source Codes: 
PDQ Closed Trial Search ID 538747
PDQ Open Trial Search ID 538747 (check for NCI PDQ open clinical trial info)
UMLS CUI C0916470

Other Properties:
     Name Value (qualifiers indented underneath)
code C67042
Legacy_Concept_Name CBT-1
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67042

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