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Version: 16.11d (Release date: 2016-11-28)
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Fas Receptor Agonist APO010 (Code C67041)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fas Receptor Agonist APO010

Definition: A recombinant, soluble, hexameric fusion protein consisting of three human Fas ligand (FasL) extracellular domains fused to the dimer-forming collagen domain of human adiponectin with potential pro-apoptotic and antineoplastic activities. Assembled into a soluble hexameric structure mimicking the ligand clustering of endogenous active FasL, Fas receptor agonist APO010 activates the Fas receptor, resulting in caspase-dependent apoptosis in susceptible tumor cell populations. FasL is a transmembrane protein of the tumor necrosis factor (TNF) superfamily and a pro-apoptotic ligand for the death receptor Fas.

Label: Fas Receptor Agonist APO010

NCI Thesaurus Code: C67041 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879517  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
APO010
Fas Receptor Agonist APO010
Mega-FasLigand

External Source Codes: 
PDQ Closed Trial Search ID 539307
PDQ Open Trial Search ID 539307 (check for NCI PDQ open clinical trial info)
UMLS CUI C1879517

Other Properties:
Name Value (qualifiers indented underneath)
code C67041
Legacy_Concept_Name APO010
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C67041

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