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Version: 17.12d (Release date: 2017-12-26)
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Palifosfamide (Code C66990)

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Terms & Properties

Preferred Name: Palifosfamide

Definition: A synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide.

Display Name: Palifosfamide

Label: Palifosfamide

NCI Thesaurus Code: C66990 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0064039  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Isophosphoramide Mustard-Lysine
N,N'-Di-(2-chloroethyl)phosphorodiamidic Acid

External Source Codes: 
CAS Registry Number 31645-39-3 (see NLM ChemIDplus info)
FDA UNII Code 6A4U6NN813
NSC Code 297900 (see NCI DTP info)
PDQ Closed Trial Search ID 538996
PDQ Open Trial Search ID 538996 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 6821629 (see PubMed Primary Reference info)
UMLS CUI C0064039

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C4H11Cl2N2O2P
code C66990
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Isophosphoramide_Mustard-Lysine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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