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Version: 17.06d (Release date: 2017-06-26)
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Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225 (Code C66987)

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Terms & Properties

Preferred Name: Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225

Definition: A folate receptor-targeting cytotoxic agent with potential antineoplastic activity. Folate receptor-targeted vinca alkaloid/mitomycin C EC0225 contains two potent cytotoxic agents, a vinca alkaloid and mitomycin C, linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the cytotoxic agents directly into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis. Mitomycin C alkylates DNA, producing DNA cross-links and inhibiting DNA replication. The relative tumor cell specificity of EC0225 reduces the toxicity profiles of its cytotoxic agent moieties.

Display Name: Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225

Label: Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225

NCI Thesaurus Code: C66987 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880433  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Folate Linked Vinca Alkaloid/Mitomycin C EC0225
Folate Receptor-Targeted Vinca Alkaloid/Mitomycin C EC0225

External Source Codes: 
PDQ Closed Trial Search ID 539691
PDQ Open Trial Search ID 539691 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880433

Other Properties:
     Name Value (qualifiers indented underneath)
code C66987
Contributing_Source CTRP
Legacy_Concept_Name EC0225
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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