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Version: 17.06d (Release date: 2017-06-26)
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Tergenpumatucel-L (Code C66985)

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Terms & Properties

Preferred Name: Tergenpumatucel-L

Definition: An allogeneic lung cancer vaccine with potential immunostimulating and antineoplastic activities. Derived from allogeneic lung tumor cells, tergenpumatucel-L is engineered to express the murine alpha-1,3-galactosyltransferase (GalT), an enzyme humans lack. GalT catalyzes the expression of foreign alpha-1,3-galactosyl (alpha-gal) carbohydrate epitopes in glycoproteins and in glycolipids on the cell membranes of the allogeneic lung tumor cells present in the vaccine, essentially producing a 'xenograft'. The hyperacute rejection involves pre-existing human anti-alpha-gal antibodies that bind the foreign alpha-gal epitopes expressed by the vaccine tumor cell xenograft, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) towards endogenous lung tumor cells with unmodified carbohydrate epitopes.

Display Name: Tergenpumatucel-L

Label: Tergenpumatucel-L

NCI Thesaurus Code: C66985 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1879682  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hyperacute Lung Cancer Vaccine
Tergenpumatucel-L

External Source Codes: 
PDQ Closed Trial Search ID 539100
PDQ Open Trial Search ID 539100 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 15161001 (see PubMed Primary Reference info)
UMLS CUI C1879682

Other Properties:
     Name Value (qualifiers indented underneath)
code C66985
Contributing_Source CTRP
Legacy_Concept_Name Alpha-1_3-Galactosyltransferase-Expressing_Allogeneic_Lung_Tumor_Cell_Vaccine
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66985

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