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Version: 17.06d (Release date: 2017-06-26)
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Daniquidone (Code C66984)

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Terms & Properties

Preferred Name: Daniquidone

Definition: A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It may kill cancer cells by causing damage to the DNA. Batracylin is a type of heterocyclic aryl amine.

Display Name: Daniquidone

Label: Daniquidone

NCI Thesaurus Code: C66984 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0053006  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
8-Aminoisoindolo(1,2-b)quinazolin-12(10H)-one
batracylin
Batracylin
Bay H 2049
Daniquidone
DANIQUIDONE

External Source Codes: 
CAS Registry Number 67199-66-0 (see NLM ChemIDplus info)
FDA UNII Code E780TX33D2
NSC Code 320846 (see NCI DTP info)
PDQ Closed Trial Search ID 539029
PDQ Open Trial Search ID 539029 (check for NCI PDQ open clinical trial info)
UMLS CUI C0053006

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H11N3O
code C66984
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Daniquidone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66984

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