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Version: 17.06d (Release date: 2017-06-26)
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Elotuzumab (Code C66982)

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Terms & Properties

Preferred Name: Elotuzumab

Definition: A humanized monoclonal antibody directed against the human CS1 (CD2 subset 1, CRACC, SLAMF7) antigen with potential antineoplastic activity. Elotuzumab binds to the CS1 antigen, which may trigger antibody-dependent cellular cytotoxicity (ADCC) in cells expressing CS1. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is highly expressed by multiple myeloma cells, but minimally expressed by normal cells.

NCI-GLOSS Definition: A monoclonal antibody being studied in the treatment of advanced multiple myeloma. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. HuLuc63 binds to CS1, a protein that is found mainly on the surface of multiple myeloma cells.

Display Name: Elotuzumab

Label: Elotuzumab

NCI Thesaurus Code: C66982 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832049  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-901608
Elotuzumab
ELOTUZUMAB
Empliciti
HuLuc-63
HuLuc63
PDL-063
PDL063

External Source Codes: 
CAS Registry Number 915296-00-3 (see NLM ChemIDplus info)
FDA UNII Code 1351PE5UGS
PDQ Closed Trial Search ID 532249
PDQ Open Trial Search ID 532249 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832049

Other Properties:
     Name Value (qualifiers indented underneath)
code C66982
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CS1_Monoclonal_Antibody_HuLuc63
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66982

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