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Version: 17.06d (Release date: 2017-06-26)
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Odanacatib (Code C66981)

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Terms & Properties

Preferred Name: Odanacatib

Definition: An inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.

Label: Odanacatib

NCI Thesaurus Code: C66981 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2351970  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 603139-19-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 531150
PDQ Open Trial Search ID 531150 (check for NCI PDQ open clinical trial info)
UMLS CUI C2351970

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H27F4N3O3S
code C66981
Contributing_Source FDA
Legacy_Concept_Name MK0822
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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