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Version: 17.06d (Release date: 2017-06-26)
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Odanacatib (Code C66981)

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Terms & Properties

Preferred Name: Odanacatib

Definition: An inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.

Label: Odanacatib

NCI Thesaurus Code: C66981 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2351970  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-(((1S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)(1,1'-biphenyl)-4-yl)ethyl)amino)pentanamide
MK0822
Odanacatib
ODANACATIB

External Source Codes: 
CAS Registry Number 603139-19-1 (see NLM ChemIDplus info)
FDA UNII Code N673F6W2VH
PDQ Closed Trial Search ID 531150
PDQ Open Trial Search ID 531150 (check for NCI PDQ open clinical trial info)
UMLS CUI C2351970

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H27F4N3O3S
code C66981
Contributing_Source FDA
Legacy_Concept_Name MK0822
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66981

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