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Version: 17.06d (Release date: 2017-06-26)
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Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104 (Code C66980)

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Terms & Properties

Preferred Name: Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104

Definition: An allogeneic human cytotoxic T-lymphocyte cell line (TALL-104) with potential antineoplastic activity. TALL-104 is an IL-2-dependent human leukemic T cell line, expressing CD8 and T-cell receptor CD3, but not CD16. Because these cells are endowed with MHC-non-restricted killer activity, TALL-104 has destructive potential against a broad range of tumors, while sparing normal cells. Upon administration, TALL-104 targets and interacts with tumor cells and activates apoptotic and necrotic pathways, eventually leading to lysis of tumor cells. In addition, TALL-104 may induce secretion of various cytokines, such as interferon-gamma, thereby potentially enhancing the cytotoxic activity.

Display Name: Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104

Label: Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104

NCI Thesaurus Code: C66980 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832042  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Human MHC Non-Restricted Cytotoxic T-Cell Line TALL-104
TALL-104

External Source Codes: 
PDQ Closed Trial Search ID 531055
PDQ Open Trial Search ID 531055 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832042

Other Properties:
     Name Value (qualifiers indented underneath)
code C66980
Contributing_Source CTRP
Legacy_Concept_Name Human_MHC_Non-Restricted_Cytotoxic_T-Cell_Line_TALL-104
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66980

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