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Version: 17.06d (Release date: 2017-06-26)
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Fidaxomicin (Code C66979)

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Terms & Properties

Preferred Name: Fidaxomicin

Definition: A narrow-spectrum, 18-membered macrolide antibiotic isolated from the actinomycete Dactylosporangium aurantiacum subsp. hamdenensis with potential antibacterial activity. Although the exact mechanism of action has yet to be fully elucidated, fidaxomicin may bind to and inhibit bacterial DNA-dependent RNA polymerase, thereby inhibiting the initiation of bacterial RNA synthesis. When orally administered, this agent is minimally absorbed into the systemic circulation, acting locally in the gastrointestinal tract. Fidaxomicin appears to be active against pathogenic Gram-positive bacteria, such as clostridia, enterococci, and staphylococci, but does not appear to be active against other beneficial intestinal bacteria.

NCI-GLOSS Definition: A substance being studied in the treatment of diarrhea caused by infection with Clostridium difficile (a type of bacteria that can grow without oxygen) in cancer patients. OPT-80 is a type of antibiotic.

Display Name: Fidaxomicin

Label: Fidaxomicin

NCI Thesaurus Code: C66979 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0065023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Clostomicin B1
Lipiarmycin A3
Tiacumicin B
tiacumicin B

External Source Codes: 
CAS Registry Number 873857-62-6 (see NLM ChemIDplus info)
CAS Registry Number 56645-60-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 530629
PDQ Open Trial Search ID 530629 (check for NCI PDQ open clinical trial info)
UMLS CUI C0065023

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Clostridial Infection
Chemical_Formula C52H74Cl2O18
code C66979
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tiacumicin_B
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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