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Version: 16.10e (Release date: 2016-10-31)
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Interferon-gamma-expressing Adenovirus Vaccine ASN-002 (Code C66972)

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Terms & Properties

Preferred Name: Interferon-gamma-expressing Adenovirus Vaccine ASN-002

Definition: A replication-defective adenoviral serotype 5 vector encoding a recombinant form of the human cytokine interferon-gamma (IFN-g), with potential antineoplastic and immunoregulatory activities. Upon intratumoral administration, the sustained expression of IFN-g by IFN-g-expressing adenovirus vaccine ASN-002 promotes a T-helper type 1 (Th1) immune response and inhibits the Th2-mediated cytokine production observed in many cutaneous lymphomas. IFN-g also mediates interleukin-12 (IL-12) production by antigen-presenting cells (APCs); activates macrophages, cytotoxic T-cells, and natural killer (NK) cells; upregulates major histocompatibility complex (MHC) molecules; and stimulates antibody-dependent cellular cytotoxicity (ADCC). Altogether, these IFN-g-mediated effects may result in both an inhibition of tumor cell proliferation and tumor cell death. Compared to IFN-g injections, the prolonged local production of IFN-g at the tumor site allows for higher efficacy and a reduction of systemic toxicity.

Label: Interferon-gamma-expressing Adenovirus Vaccine ASN-002

NCI Thesaurus Code: C66972 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832028  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-IFNg
ASN-002
INFg-expressing Ad Vaccine ASN-002
Interferon-gamma-expressing Adenovirus Vaccine ASN-002
TG1042

External Source Codes: 
PDQ Closed Trial Search ID 530060
PDQ Open Trial Search ID 530060 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832028

Other Properties:
Name Value (qualifiers indented underneath)
code C66972
Legacy_Concept_Name Adenovirus-Interferon-Gamma_TG1042
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66972

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