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Version: 16.11d (Release date: 2016-11-28)
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Checkpoint Kinase Inhibitor AZD7762 (Code C66961)

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Terms & Properties

Preferred Name: Checkpoint Kinase Inhibitor AZD7762

Definition: A synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.

Display Name: Checkpoint Kinase Inhibitor AZD7762

Label: Checkpoint Kinase Inhibitor AZD7762

NCI Thesaurus Code: C66961 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832037  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD7762
Checkpoint Kinase Inhibitor AZD7762

External Source Codes: 
PDQ Closed Trial Search ID 530784
PDQ Open Trial Search ID 530784 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832037

Other Properties:
Name Value (qualifiers indented underneath)
code C66961
Contributing_Source CTRP
Legacy_Concept_Name AZD7762
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66961

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