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Version: 17.06d (Release date: 2017-06-26)
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Tibolone (Code C66955)

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Terms & Properties

Preferred Name: Tibolone

Definition: A synthetic anabolic steroid with estrogenic, androgenic and progestagenic activities. The 3alpha- and 3beta-hydroxy metabolites of tibilone activate estrogenic receptors (ERs) in bone and vaginal tissue leading to a decrease in bone turnover, and decreased vaginal dryness, respectively; derived from the 3beta-hydroxy metabolite, its delta4-isomer activates androgenic receptors (ARs) in the brain and liver and progestogenic receptors (PRs) in endometrial tissue, affecting sexual function, lipid metabolism, and endometrial function, respectively. In breast and endometrial tissue, tibolone metabolites inhibit sulfatase, preventing the conversion of circulating estrone sulfate and estradiol sulfate to estrone and estradiol, respectively; estrogen-mediated effects in the breast and uterus are thus reduced.

Label: Tibolone

NCI Thesaurus Code: C66955 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0076660  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 5630-53-5 (see NLM ChemIDplus info)
FDA UNII Code FF9X0205V2
ChEBI ID CHEBI:32223 (see ChEBI info)
PDQ Closed Trial Search ID 530794
PDQ Open Trial Search ID 530794 (check for NCI PDQ open clinical trial info)
UMLS CUI C0076660

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H28O2
code C66955
Contributing_Source FDA
Legacy_Concept_Name Tibolone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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