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Version: 17.06d (Release date: 2017-06-26)
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Belotecan Hydrochloride (Code C66954)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Belotecan Hydrochloride

Definition: The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.

NCI-GLOSS Definition: A substance being studied in the treatment of small cell lung cancer and other types of cancer. It blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of camptothecin analog and a type of topoisomerase inhibitor.

Label: Belotecan Hydrochloride

NCI Thesaurus Code: C66954 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0762739  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Belotecan Hydrochloride
BELOTECAN HYDROCHLORIDE
belotecan hydrochloride
CKD602 HCl

External Source Codes: 
CAS Registry Number 213819-48-8 (see NLM ChemIDplus info)
FDA UNII Code 01DZ4127G7
PDQ Closed Trial Search ID 537355
PDQ Open Trial Search ID 537355 (check for NCI PDQ open clinical trial info)
UMLS CUI C0762739

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H27N3O4.ClH
code C66954
Contributing_Source FDA
Legacy_Concept_Name Belotecan_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66954

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