|Belotecan Hydrochloride (Code C66954)|
|Terms & Properties|
Preferred Name: Belotecan Hydrochloride
Definition: The hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.
NCI-GLOSS Definition: A substance being studied in the treatment of small cell lung cancer and other types of cancer. It blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of camptothecin analog and a type of topoisomerase inhibitor.
Label: Belotecan Hydrochloride
NCI Metathesaurus Link: C0762739 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||213819-48-8 (see NLM ChemIDplus info)|
|FDA UNII Code||01DZ4127G7|
|PDQ Closed Trial Search ID||537355|
|PDQ Open Trial Search ID||537355 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|