skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Ofatumumab (Code C66952)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ofatumumab

Definition: A fully human, high-affinity IgG1 monoclonal antibody directed against the B cell CD20 cell surface antigen with potential antineoplastic activity. Ofatumumab binds specifically to CD20 on the surfaces of B cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B cells overexpressing CD20. The CD20 antigen, found on over 90% of B cells, B cell lymphomas, and other B cells of lymphoid tumors of B cell origin, is a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel; it is exclusively expressed on B cells during most stages of B cell development.

NCI-GLOSS Definition: A drug used to treat chronic lymphocytic leukemia (CLL) that has not gotten better with other chemotherapy. It is also being studied in the treatment of other types of cancer, including follicular non-Hodgkin lymphoma. Arzerra binds to CD20, a protein on the surface of normal B cells and most B-cell tumors. This may kill the cancer cells. It is a type of monoclonal antibody.

Display Name: Ofatumumab

Label: Ofatumumab

NCI Thesaurus Code: C66952 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832027  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Arzerra
GSK1841157
HuMax-CD20
HuMax-CD20, 2F2
Ofatumumab
ofatumumab
OFATUMUMAB

External Source Codes: 
CAS Registry Number 679818-59-8 (see NLM ChemIDplus info)
FDA UNII Code M95KG522R0
PDQ Closed Trial Search ID 530015
PDQ Open Trial Search ID 530015 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832027

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For chronic lymphocytic leukemia
code C66952
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ofatumumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66952

Mainbox Bottom