skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Panobinostat (Code C66948)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Panobinostat

Definition: A cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.

NCI-GLOSS Definition: A drug being studied in the treatment of cancer. It blocks enzymes needed for cells to grow and divide and may kill cancer cells. Panobinostat may also prevent the growth of new blood vessels that tumors need to grow. It is a type of histone deacetylase inhibitor and a type of antiangiogenesis agent.

Display Name: Panobinostat

Label: Panobinostat

NCI Thesaurus Code: C66948 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1998098  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2E)-N-hydroxy-3-(4-(((2-(2-methyl-1h-indol-3-yl)ethyl)amino)methyl)phenyl)prop-2-enamide
Faridak
Farydak
LBH589
Panobinostat
PANOBINOSTAT
panobinostat

External Source Codes: 
CAS Registry Number 404950-80-7 (see NLM ChemIDplus info)
FDA UNII Code 9647FM7Y3Z
PDQ Closed Trial Search ID 530790
PDQ Open Trial Search ID 530790 (check for NCI PDQ open clinical trial info)
UMLS CUI C1998098

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H23N3O2
code C66948
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name LBH589
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66948

Mainbox Bottom