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Version: 17.06d (Release date: 2017-06-26)
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Dexrazoxane Hydrochloride (Code C66945)

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Terms & Properties

Preferred Name: Dexrazoxane Hydrochloride

Definition: The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition.

NCI-GLOSS Definition: A drug used to treat severe side effects caused by certain anticancer drugs. It is used under the brand name Totect to treat the toxic effects of an anticancer drug that leaks from a vein into surrounding tissue and causes tissue damage. It is also used under the brand name Zinecard to reduce heart damage in women given doxorubicin for breast cancer that has spread. Dexrazoxane hydrochloride is also being studied in the treatment of cancer. It is a type of cardioprotective agent, a type of chemoprotective agent, and a type of topoisomerase inhibitor.

Display Name: Dexrazoxane Hydrochloride

Label: Dexrazoxane Hydrochloride

NCI Thesaurus Code: C66945 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0982118  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cardioxane
Dexrazoxane Hydrochloride
dexrazoxane hydrochloride
DEXRAZOXANE HYDROCHLORIDE
Totect
Zinecard

External Source Codes: 
CAS Registry Number 149003-01-0 (see NLM ChemIDplus info)
FDA UNII Code 5346058Q7S
ChEBI ID CHEBI:50224 (see ChEBI info)
PDQ Closed Trial Search ID 39485
PDQ Open Trial Search ID 39485 (check for NCI PDQ open clinical trial info)
UMLS CUI C0982118

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For severe side effects caused by certain types of chemotherapy including extravasation, cardiac side effects by doxorubicin.
Chemical_Formula C11H16N4O4.HCl
code C66945
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dexrazoxane_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66945

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