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Version: 17.06d (Release date: 2017-06-26)
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Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter (Code C66942)

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Terms & Properties

Preferred Name: Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter

Definition: An attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with potential antineoplastic activity. The cellular receptor of MV is human CD46 antigen, a type 1 integral membrane glycoprotein found on nearly all human tissues and overexpressed on many cancer cell types. After attachment to and fusion of host cell membranes, MV-NIS induces syncytia and cell lysis. When combined with radioiodine 123 (I-123), expressed NIS facilitates uptake of I-123 into MV-infected cells, thereby allowing for noninvasive imaging of viral gene expression. MV-NIS also enhances the oncolytic activity of MV against radiosensitive tumor cells by additional destruction of the MV-infected cells when using iodine-131.

Display Name: Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter

Label: Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter

NCI Thesaurus Code: C66942 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1882146  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MV-NIS
Oncolytic Measles Virus Encoding Thyroidal Sodium Iodide Symporter

External Source Codes: 
PDQ Closed Trial Search ID 538262
PDQ Open Trial Search ID 538262 (check for NCI PDQ open clinical trial info)
UMLS CUI C1882146

Other Properties:
     Name Value (qualifiers indented underneath)
code C66942
Contributing_Source CTRP
Legacy_Concept_Name Oncolytic_Measles_Virus_Encoding_Thyroidal_Sodium_Iodide_Symporter
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66942

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