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Version: 17.12d (Release date: 2017-12-26)
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Crolibulin (Code C66938)

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Terms & Properties

Preferred Name: Crolibulin

Definition: A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.

Display Name: Crolibulin

Label: Crolibulin

NCI Thesaurus Code: C66938 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880474  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Microtubule Inhibitor EPC2407

External Source Codes: 
CAS Registry Number 1000852-17-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 536028
PDQ Open Trial Search ID 536028 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880474

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H17BrN4O3
code C66938
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EPC2407
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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