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Version: 17.06d (Release date: 2017-06-26)
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Crolibulin (Code C66938)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Crolibulin

Definition: A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.

Display Name: Crolibulin

Label: Crolibulin

NCI Thesaurus Code: C66938 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880474  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Crolibulin
CROLIBULIN
EPC2407
Microtubule Inhibitor EPC2407

External Source Codes: 
CAS Registry Number 1000852-17-4 (see NLM ChemIDplus info)
FDA UNII Code 9ENT43KY91
PDQ Closed Trial Search ID 536028
PDQ Open Trial Search ID 536028 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880474

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H17BrN4O3
code C66938
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name EPC2407
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66938

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