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Version: 16.11d (Release date: 2016-11-28)
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Cabazitaxel (Code C66937)

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Terms & Properties

Preferred Name: Cabazitaxel

Definition: A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

NCI-GLOSS Definition: A drug used with prednisone to treat hormone-resistant prostate cancer that has spread and that had been treated with docetaxel. It is also being studied in the treatment of other types of cancer. Cabazitaxel blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent.

Display Name: Cabazitaxel

Label: Cabazitaxel

NCI Thesaurus Code: C66937 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830183  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate]
Cabazitaxel
CABAZITAXEL
cabazitaxel
Jevtana
RPR-116258A
Taxoid XRP6258
taxoid XRP6258
XRP-6258

External Source Codes: 
CAS Registry Number 183133-96-2 (see NLM ChemIDplus info)
FDA UNII Code 51F690397J
ChEBI ID CHEBI:63584 (see ChEBI info)
PDQ Closed Trial Search ID 534131
PDQ Open Trial Search ID 534131 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830183

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For metastatic hormone-refractory prostate cancer
Chemical_Formula C45H57NO14
code C66937
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name XRP6258
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66937

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