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Version: 17.06d (Release date: 2017-06-26)
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Gataparsen Sodium (Code C66935)

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Terms & Properties

Preferred Name: Gataparsen Sodium

Definition: A second-generation antisense oligonucleotide against survivin mRNA with potential antitumor activity. Oligonucleotide LY2181308 hybridizes to survivin mRNA, thereby blocking translation of survivin protein, a member of the inhibitor of apoptosis (IAP) family. Survivin, expressed during embryonal development, is upregulated in a variety of human cancers while absent in most normal adult cells; its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Silencing expression of survivin potentially leads to restoration of the apoptotic process in cancer cells, thereby facilitating chemotherapeutic treatments.

Display Name: Gataparsen Sodium

Label: Gataparsen Sodium

NCI Thesaurus Code: C66935 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1832051  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antisurvivin Antisense Oligonucleotide LY2181308
Gataparsen Sodium
LY2181308
LY2181308 Heptadecasodium Salt

External Source Codes: 
CAS Registry Number 928768-71-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 532253
PDQ Open Trial Search ID 532253 (check for NCI PDQ open clinical trial info)
UMLS CUI C1832051

Other Properties:
     Name Value (qualifiers indented underneath)
code C66935
Contributing_Source CTRP
Legacy_Concept_Name LY2181308
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66935

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