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Version: 17.06d (Release date: 2017-06-26)
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Dapsone Gel (Code C66931)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dapsone Gel

Definition: The 5% gel preparation of dapsone, a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.

Display Name: Dapsone Gel

Label: Dapsone Gel

NCI Thesaurus Code: C66931 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1639494  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5% Dapsone Gel
Aczone Gel
Dapsone Gel
Dapsone Gel, 5%

External Source Codes: 
PDQ Closed Trial Search ID 494632
PDQ Open Trial Search ID 494632 (check for NCI PDQ open clinical trial info)
UMLS CUI C1639494

Other Properties:
     Name Value (qualifiers indented underneath)
code C66931
Contributing_Source CTRP
Legacy_Concept_Name Dapsone_Gel
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66931

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