skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Oblimersen Sodium (Code C66722)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Oblimersen Sodium

Definition: The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide.

Display Name: Oblimersen Sodium

Label: Oblimersen Sodium

NCI Thesaurus Code: C66722 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935954  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anticode G3139
augmerosen
Augmerosen
BCL-2 Antisense/G3139
BCL-2 Antisense Oligodeoxynucleotide G3139
bcl-2 antisense oligodeoxynucleotide G3139
G3139
G3139 Antisense Oligonucleotide
G3139 BCL-2 Antisense Oligo
G3139 BCL-2 Antisense Oligodeoxynucleotide
G3139 BCL-2 Antisense Oligonucleotide
Genasense
Oblimersen Sodium
oblimersen sodium
OBLIMERSEN SODIUM

External Source Codes: 
CAS Registry Number 190977-41-4 (see NLM ChemIDplus info)
FDA UNII Code SH55B0RQ9K
NSC Code 683428 (see NCI DTP info)
PDQ Closed Trial Search ID 42935
PDQ Open Trial Search ID 42935 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935954

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C172H204N62O91P17S17.17Na
code C66722
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Oblimersen_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66722

Mainbox Bottom