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Version: 17.12d (Release date: 2017-12-26)
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Levoleucovorin Calcium (Code C66721)

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Terms & Properties

Preferred Name: Levoleucovorin Calcium

Definition: A levo isoform of leucovorin calcium with antineoplastic activity. Levoleucovorin is an active metabolite of folic acid, which does not require metabolism by dihydrofolate reductase. This agent counteracts the toxic effects of other folic acid derivative agents, rescuing the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity.

NCI-GLOSS Definition: A drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Calcium levoleucovorin is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Calcium levoleucovorin is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent.

Label: Levoleucovorin Calcium

NCI Thesaurus Code: C66721 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1881372  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
calcium levoleucovorin
Levoleucovorin Calcium

External Source Codes: 
CAS Registry Number 80433-71-2 (see NLM ChemIDplus info)
UMLS CUI C1881372

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Colorectal Cancer
Chemical_Formula C20H21N7O7.Ca
code C66721
Contributing_Source FDA
Legacy_Concept_Name Levoleucovorin_Calcium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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