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Version: 16.11d (Release date: 2016-11-28)
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Telbivudine (Code C66584)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Telbivudine

Definition: A synthetic thymidine nucleoside analogue with antiviral activity highly specific for the treatment of hepatitis B virus (HBV). Intracellularly, telbivudine is phosphorylated to its active metabolite, telbivudine triphosphate. The dideoxy telbivudine triphosphate competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). This results in the blockade of HBV DNA replication and viral propagation.

Label: Telbivudine

NCI Thesaurus Code: C66584 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1453933  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
Beta-L-Thymidine
Epavudine
L-dT
L-Thymidine
LdT
LDT600
NB 02B
NV-02B
TELBIVUDINE
Telbivudine
Tyzeka

External Source Codes: 
CAS Registry Number 3424-98-4 (see NLM ChemIDplus info)
FDA UNII Code 2OC4HKD3SF
ChEBI ID CHEBI:63624 (see ChEBI info)
PDQ Closed Trial Search ID 671737
PDQ Open Trial Search ID 671737 (check for NCI PDQ open clinical trial info)
UMLS CUI C1453933

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic Hepatitis B
Chemical_Formula C10H14N2O5
code C66584
Contributing_Source FDA
Legacy_Concept_Name Telbivudine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66584

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