skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Silver Sulfadiazine (Code C66567)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Silver Sulfadiazine

Definition: A sulfonamide-based topical agent with antibacterial and antifungal activity. Silver sulfadiazine may act through a combination of the activity of silver and sulfadiazine. When this agent interacts with sodium chloride-containing body fluids, silver ions are released slowly and sustainably into wounded areas. Ionized silver atoms catalyze the formation of disulfide bonds leading to protein structural changes and inactivating thiol-containing enzymes; silver ions may also intercalate DNA thereby interfering with replication and transcription of bacteria. As a competitive inhibitor of para-aminobenzoic acid (PABA), sulfadiazine inhibits bacterial dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.

Label: Silver Sulfadiazine

NCI Thesaurus Code: C66567 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0037134  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Flamazine
Silvadene
Silver Sulfadiazine
SILVER SULFADIAZINE
Sliverex
SSD
Sulfadiazine Silver
Thermazene

External Source Codes: 
CAS Registry Number 22199-08-2 (see NLM ChemIDplus info)
FDA UNII Code W46JY43EJR
ChEBI ID CHEBI:9142 (see ChEBI info)
PDQ Closed Trial Search ID 717602
PDQ Open Trial Search ID 717602 (check for NCI PDQ open clinical trial info)
UMLS CUI C0037134

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H9N4O2S.Ag
code C66567
Contributing_Source FDA
Legacy_Concept_Name Sulfadiazine_Silver
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66567

Mainbox Bottom