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Version: 17.06d (Release date: 2017-06-26)
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Ramelteon (Code C66504)

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Terms & Properties

Preferred Name: Ramelteon

Definition: A synthetic melatonin analogue with hypnotic and circadian rhythm-modulating activities. Ramelteon binds to and activates melatonin receptors 1 and 2 in the suprachiasmatic nucleus (SCN) of the brain, thereby promoting the onset of sleep. Unlike the nonbenzodiazepine sedative hypnotics zolpidem and zaleplon, this agent does not activate GABA receptors and, so, produces no GABA receptor-mediated anxiolytic, myorelaxant, and amnesic effects.

Label: Ramelteon

NCI Thesaurus Code: C66504 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1565316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 196597-26-9 (see NLM ChemIDplus info)
FDA UNII Code 901AS54I69
PDQ Closed Trial Search ID 598363
PDQ Open Trial Search ID 598363 (check for NCI PDQ open clinical trial info)
UMLS CUI C1565316

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H21NO2
code C66504
Contributing_Source FDA
Legacy_Concept_Name Ramelteon
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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