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Version: 17.06d (Release date: 2017-06-26)
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Mitoxantrone Hydrochloride (Code C665)

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Terms & Properties

Preferred Name: Mitoxantrone Hydrochloride

Definition: The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.

NCI-GLOSS Definition: A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.

Display Name: Mitoxantrone Hydrochloride

Label: Mitoxantrone Hydrochloride

NCI Thesaurus Code: C665 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700458  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone Dihydrochloride
CL 232315
DHAD
DHAQ
Dihydroxyanthracenedione Dihydrochloride
Mitoxantrone Dihydrochloride
Mitoxantrone Hydrochloride
MITOXANTRONE HYDROCHLORIDE
Mitoxantroni Hydrochloridum
Mitozantrone Hydrochloride
Mitroxone
Neotalem
Novantrone
Onkotrone
Pralifan

External Source Codes: 
CAS Registry Number 70476-82-3 (see NLM ChemIDplus info)
FDA UNII Code U6USW86RD0
ChEBI ID CHEBI:50727 (see ChEBI info)
NSC Code 301739 (see NCI DTP info)
PDQ Closed Trial Search ID 39219
PDQ Open Trial Search ID 39219 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700458

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute Leukemia; Breast cancer; Non Hodgkins Lymphoma; Multiple sclerosis; Prostate cancer
Chemical_Formula C22H28N4O6.2HCl
code C665
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mitoxantrone
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C665

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