skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Mitotane (Code C664)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Mitotane

Definition: A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)

NCI-GLOSS Definition: An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).

Display Name: Mitotane

Label: Mitotane

NCI Thesaurus Code: C664 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0026256  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(o,p)-DDD
1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane
2,4'-Dichlorodiphenyldichloroethane
2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane
2, 4'-Dichlorodiphenyldichloroethane
2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane
CB-313
CB 313
Chloditan
Chlodithane
DDD
Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-
Khloditan
Lisodren
Lysodren
Mitotane
mitotane
MITOTANE
Mytotan
o,p'-DDD
o,p' - DDD
Ortho,para-DDD
WR-13045

External Source Codes: 
CAS Registry Number 53-19-0 (see NLM ChemIDplus info)
FDA UNII Code 78E4J5IB5J
NSC Code 38721 (see NCI DTP info)
PDQ Closed Trial Search ID 39506
PDQ Open Trial Search ID 39506 (check for NCI PDQ open clinical trial info)
UMLS CUI C0026256

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Adrenocortical carcinoma
Chemical_Formula C14H10Cl4
code C664
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mitotane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C664

Mainbox Bottom