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Version: 17.06d (Release date: 2017-06-26)
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Phenprocoumon (Code C66374)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Phenprocoumon

Definition: An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation.

Label: Phenprocoumon

NCI Thesaurus Code: C66374 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0031444  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2H-1-Benzopyran-2-one, 4-Hydroxy-3-(1-phenylpropyl)-
3-(alpha-Phenylpropyl)-4-hydroxycoumarin
Liquamar
PHENPROCOUMON
Phenprocoumon

External Source Codes: 
CAS Registry Number 435-97-2 (see NLM ChemIDplus info)
FDA UNII Code Q08SIO485D
ChEBI ID CHEBI:50438 (see ChEBI info)
PDQ Closed Trial Search ID 750561
PDQ Open Trial Search ID 750561 (check for NCI PDQ open clinical trial info)
UMLS CUI C0031444

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H16O3
code C66374
Contributing_Source FDA
Legacy_Concept_Name Phenprocoumon
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66374

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