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Version: 17.06d (Release date: 2017-06-26)
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Mitoguazone (Code C661)

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Terms & Properties

Preferred Name: Mitoguazone

Definition: A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)

Label: Mitoguazone

NCI Thesaurus Code: C661 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0026251  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,1'-((methylethanediylidene)dinitrilo)diguanidine
2,2"-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]
DRG-0223
Me-GAG
Methyl-G
Methyl-GAG
Methylglyoxal bis(amidinohydrazone)
methylglyoxal bis(guanylhydrazone)
Methylglyoxal Bisguanylhydrazone
Methyl GAG
MGBG
Mitoguazone
MITOGUAZONE
pyruvaldehyde bis(amidinohydrazone)
Zyrkamine

External Source Codes: 
CAS Registry Number 459-86-9 (see NLM ChemIDplus info)
FDA UNII Code OD5Q0L447W
NSC Code 32946 (see NCI DTP info)
PDQ Closed Trial Search ID 39500
PDQ Open Trial Search ID 39500 (check for NCI PDQ open clinical trial info)
UMLS CUI C0026251

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H12N8
code C661
Contributing_Source FDA
Legacy_Concept_Name Mitoguazone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C661

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