skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Mangafodipir Trisodium (Code C66053)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Mangafodipir Trisodium

Definition: The trisodium salt of mangafodipir with potential antioxidant and chemoprotective activities. Consisting of manganese (II) ions chelated to fodipir (dipyridoxyl diphosphate or DPDP), mangafodipir scavenges oxygen free radicals such as superoxide anion, hydrogen peroxide, and hydroxyl radical, potentially preventing oxygen free radical damage to macromolecules such as DNA and minimizing oxygen free radical-related chemotoxicity in normal tissues. However, this agent may potentiate the chemotherapy-induced generation of oxygen free radicals in tumor cells, resulting in the potentiation of chemotherapy-induced cytotoxicity; tumor cells, with higher levels of reactive oxygen species than normal cells, possess a lower threshold for oxygen free radical-mediated cytotoxicity. Mangafodipir is traditionally used as an imaging agent in magnetic resonance imaging (MRI).

Label: Mangafodipir Trisodium

NCI Thesaurus Code: C66053 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0067297  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mangafodipir Trisodium
MANGAFODIPIR TRISODIUM

External Source Codes: 
CAS Registry Number 140678-14-4 (see NLM ChemIDplus info)
FDA UNII Code 129FW80TG4
PDQ Closed Trial Search ID 596487
PDQ Open Trial Search ID 596487 (check for NCI PDQ open clinical trial info)
UMLS CUI C0067297

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H27N4O14P2.Mn.3Na
code C66053
Contributing_Source FDA
Legacy_Concept_Name Mangafodipir_Trisodium
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66053

Mainbox Bottom