skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Lubiprostone (Code C66040)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Lubiprostone

Definition: A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium. This produces an efflux of chloride ions, thereby drawing water into the gastrointestinal lumen. The resulting increased amounts of intestinal fluid soften the stool, increase motility, and improve bowel movements.

Label: Lubiprostone

NCI Thesaurus Code: C66040 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1684405  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Amitiza
LUBIPROSTONE
Lubiprostone

External Source Codes: 
CAS Registry Number 333963-40-9 (see NLM ChemIDplus info)
FDA UNII Code 7662KG2R6K
UMLS CUI C1684405

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic Constipation
Chemical_Formula C20H32F2O5
code C66040
Contributing_Source FDA
Legacy_Concept_Name Lubiprostone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66040

Mainbox Bottom