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Version: 17.06d (Release date: 2017-06-26)
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Levocetirizine (Code C66008)

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Terms & Properties

Preferred Name: Levocetirizine

Definition: A third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the expression of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.

Label: Levocetirizine

NCI Thesaurus Code: C66008 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1174893  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LEVOCETIRIZINE
Levocetirizine

External Source Codes: 
CAS Registry Number 130018-77-8 (see NLM ChemIDplus info)
FDA UNII Code 6U5EA9RT2O
UMLS CUI C1174893

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H25ClN2O3
code C66008
Contributing_Source FDA
Legacy_Concept_Name Levocetirizine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C66008

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