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Version: 17.06d (Release date: 2017-06-26)
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Isoflurane (Code C65978)

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Terms & Properties

Preferred Name: Isoflurane

Definition: A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.

Label: Isoflurane

NCI Thesaurus Code: C65978 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0022180  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether

External Source Codes: 
CAS Registry Number 26675-46-7 (see NLM ChemIDplus info)
ChEBI ID CHEBI:6015 (see ChEBI info)
PDQ Closed Trial Search ID 752236
PDQ Open Trial Search ID 752236 (check for NCI PDQ open clinical trial info)
UMLS CUI C0022180

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C3H2ClF5O
code C65978
Contributing_Source FDA
Legacy_Concept_Name Isoflurane
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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