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Version: 17.06d (Release date: 2017-06-26)
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Plicamycin (Code C658)

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Terms & Properties

Preferred Name: Plicamycin

Definition: An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)

NCI-GLOSS Definition: A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.

Display Name: Plicamycin

Label: Plicamycin

NCI Thesaurus Code: C658 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0026234  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
A-2371
Aureolic acid
Mithracin
Mithracine
Mithramycin
mithramycin
MTH
PA-144
Plicamycin
PLICAMYCIN
plicamycin

External Source Codes: 
CAS Registry Number 18378-89-7 (see NLM ChemIDplus info)
FDA UNII Code NIJ123W41V
ChEBI ID CHEBI:31856 (see ChEBI info)
NSC Code 24559 (see NCI DTP info)
PDQ Closed Trial Search ID 41738
PDQ Open Trial Search ID 41738 (check for NCI PDQ open clinical trial info)
UMLS CUI C0026234

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C52H76O24
code C658
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Plicamycin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C658

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