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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Misonidazole (Code C657)

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Terms & Properties

Preferred Name: Misonidazole

Definition: A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. (NCI04)

Label: Misonidazole

NCI Thesaurus Code: C657 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0026218  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole
RO 7-0582

External Source Codes: 
CAS Registry Number 13551-87-6 (see NLM ChemIDplus info)
NSC Code 261037 (see NCI DTP info)
PDQ Closed Trial Search ID 39504
PDQ Open Trial Search ID 39504 (check for NCI PDQ open clinical trial info)
UMLS CUI C0026218

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H11N3O4
code C657
Contributing_Source FDA
Legacy_Concept_Name Misonidazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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