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Version: 17.06d (Release date: 2017-06-26)
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Eszopiclone (Code C65545)

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Terms & Properties

Preferred Name: Eszopiclone

Definition: A nonbenzodiazepine, cyclopyrrolone and active stereoisomer of zopiclone with hypnotic and sedative activity and without significant anxiolytic activity. Although the exact mechanism of action remains to be fully elucidated, eszopiclone is able to bind to and activate the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous system (CNS). This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This eventually leads to a hypnotic effect and allows for an induction of sleep.

Label: Eszopiclone

NCI Thesaurus Code: C65545 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1436328  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate

External Source Codes: 
CAS Registry Number 138729-47-2 (see NLM ChemIDplus info)
ChEBI ID CHEBI:53760 (see ChEBI info)
PDQ Closed Trial Search ID 538994
PDQ Open Trial Search ID 538994 (check for NCI PDQ open clinical trial info)
UMLS CUI C1436328

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Insomnia
Chemical_Formula C17H17ClN6O3
code C65545
Contributing_Source FDA
Legacy_Concept_Name Eszopiclone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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