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Version: 17.06d (Release date: 2017-06-26)
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Eprodisate Disodium (Code C65520)

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Terms & Properties

Preferred Name: Eprodisate Disodium

Definition: The orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.

Display Name: Eprodisate Disodium

Label: Eprodisate Disodium

NCI Thesaurus Code: C65520 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880542  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Propanedisulfonic Acid, Disodium Salt
Eprodisate Disodium
EPRODISATE DISODIUM
NC 503

External Source Codes: 
CAS Registry Number 36589-58-9 (see NLM ChemIDplus info)
FDA UNII Code 5X0D9H16IU
PDQ Closed Trial Search ID 747396
PDQ Open Trial Search ID 747396 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880542

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C3H6O6S2.2Na
code C65520
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Eprodisate_Disodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C65520

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