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Version: 17.12d (Release date: 2017-12-26)
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Eprodisate Disodium (Code C65520)

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Terms & Properties

Preferred Name: Eprodisate Disodium

Definition: The orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.

Display Name: Eprodisate Disodium

Label: Eprodisate Disodium

NCI Thesaurus Code: C65520 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1880542  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Propanedisulfonic Acid, Disodium Salt
Eprodisate Disodium
NC 503

External Source Codes: 
CAS Registry Number 36589-58-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 747396
PDQ Open Trial Search ID 747396 (check for NCI PDQ open clinical trial info)
UMLS CUI C1880542

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C3H6O6S2.2Na
code C65520
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Eprodisate_Disodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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