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Version: 17.06d (Release date: 2017-06-26)
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Entecavir (Code C65513)

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Terms & Properties

Preferred Name: Entecavir

Definition: A synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription.

Label: Entecavir

NCI Thesaurus Code: C65513 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0971023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6H-Purin-6-One, 2-Amino-1,9-Dihydro-9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)- Monohydrate
9-((1S,3R,4S)-4-Hydroxy-3-(Hydroxymethyl)-2-Methylenecyclopentyl)Guanine Monohydrate

External Source Codes: 
CAS Registry Number 209216-23-9 (see NLM ChemIDplus info)
FDA UNII Code 5968Y6H45M
ChEBI ID CHEBI:59902 (see ChEBI info)
PDQ Closed Trial Search ID 617986
PDQ Open Trial Search ID 617986 (check for NCI PDQ open clinical trial info)
UMLS CUI C0971023

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H15N5O3.H2O
code C65513
Contributing_Source FDA
Legacy_Concept_Name Entecavir
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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