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Version: 17.06d (Release date: 2017-06-26)
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Mifepristone (Code C655)

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Terms & Properties

Preferred Name: Mifepristone

Definition: A derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities.

NCI-GLOSS Definition: A drug used to end early pregnancies. It is also being studied in the treatment of some types of cancer and other conditions. Mifepristone blocks the action of progesterone, a hormone that helps some cancers grow. It is a type of antiprogesterone.

Display Name: Mifepristone

Label: Mifepristone

NCI Thesaurus Code: C655 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0026088  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
11-((4-dimethylamino) phenyl)-17-Hydroxy-17-(1-propynyl) Estra-4,9- dien-3-one
11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one
Korlym
Mifegyne
Mifeprex
Mifepristone
mifepristone
MIFEPRISTONE
RU-38486
RU-486
RU 486

External Source Codes: 
CAS Registry Number 84371-65-3 (see NLM ChemIDplus info)
FDA UNII Code 320T6RNW1F
ChEBI ID CHEBI:50692 (see ChEBI info)
NSC Code 652104 (see NCI DTP info)
PDQ Closed Trial Search ID 40888
PDQ Open Trial Search ID 40888 (check for NCI PDQ open clinical trial info)
UMLS CUI C0026088

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H35NO2
code C655
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mifepristone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C655

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