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Version: 17.06d (Release date: 2017-06-26)
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Duloxetine Hydrochloride (Code C65496)

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Terms & Properties

Preferred Name: Duloxetine Hydrochloride

Definition: The hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors.

NCI-GLOSS Definition: A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes. It is also being studied in the treatment of peripheral neuropathy caused by certain anticancer drugs. Duloxetine hydrochloride increases the amount of certain chemicals in the brain that help relieve depression and pain. It is a type of serotonin and norepinephrine reuptake inhibitor.

Display Name: Duloxetine Hydrochloride

Label: Duloxetine Hydrochloride

NCI Thesaurus Code: C65496 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1505020  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cymbalta
cymbalta
Duloxetine Hydrochloride
DULOXETINE HYDROCHLORIDE
duloxetine hydrochloride

External Source Codes: 
CAS Registry Number 136434-34-9 (see NLM ChemIDplus info)
FDA UNII Code 9044SC542W
ChEBI ID CHEBI:31526 (see ChEBI info)
PDQ Closed Trial Search ID 553629
PDQ Open Trial Search ID 553629 (check for NCI PDQ open clinical trial info)
UMLS CUI C1505020

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H19NOS.HCl
code C65496
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Duloxetine_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C65496

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