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Version: 17.12d (Release date: 2017-12-26)
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Doxepin (Code C65475)

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Terms & Properties

Preferred Name: Doxepin

Definition: A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors.

Label: Doxepin

NCI Thesaurus Code: C65475 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0013085  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 1668-19-5 (see NLM ChemIDplus info)
ChEBI ID CHEBI:4710 (see ChEBI info)
UMLS CUI C0013085

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Insomnia
code C65475
Contributing_Source FDA
Legacy_Concept_Name Doxepin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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