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Version: 17.06d (Release date: 2017-06-26)
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Midazolam Hydrochloride (Code C654)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Midazolam Hydrochloride

Definition: The hydrochloride salt of a short-acting benzodiazepine derivative with an imidazole structure and anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam binds to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS), resulting in increases in the opening of chloride channels, membrane hyperpolarization, and the inhibitory effect of GABA. This agent may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft.

NCI-GLOSS Definition: A drug used to treat anxiety and tension and to relax muscles. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine.

Display Name: Midazolam Hydrochloride

Label: Midazolam Hydrochloride

NCI Thesaurus Code: C654 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700457  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
8-Chloro-6-(2-fluorophenyl)-1-Methyl- 4H- Imidazo(1,5a)(1,4)Benzodiazepine
midazolam
Midazolam Hydrochloride
midazolam hydrochloride
MIDAZOLAM HYDROCHLORIDE
Versed

External Source Codes: 
CAS Registry Number 59467-96-8 (see NLM ChemIDplus info)
FDA UNII Code W7TTW573JJ
PDQ Closed Trial Search ID 41056
PDQ Open Trial Search ID 41056 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700457

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H13ClFN3.HCl
code C654
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Midazolam
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C654

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