skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.08d (Release date: 2017-08-28)
SearchBox Top
SearchBox Bottom
Armodafinil (Code C65241)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Armodafinil

Definition: The R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. Although the exact mechanism of action has yet to be fully elucidated, armodafinil appears to inhibit the reuptake of dopamine by binding to the dopamine-reuptake pump, which leads to an increase in extracellular dopamine levels in some brain regions. This agent does not bind to or inhibit several receptors and enzymes that may be involved in sleep/wake regulation and is not a direct- or indirect-acting dopamine receptor agonist. Armodafinil has a longer half-life than modafinil.

NCI-GLOSS Definition: A drug that is used to treat certain sleep disorders, such as narcolepsy. It makes patients feel more alert and awake. It is also being studied in the treatment of insomnia and fatigue in patients treated for cancer. Armodafinil acts in a part of the brain that controls sleep and wakefulness. It is a type of wakefulness-promoting agent.

Display Name: Armodafinil

Label: Armodafinil

NCI Thesaurus Code: C65241 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1701455  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-2-((R)-(Diphenylmethyl)sulfinyl)acetamide
Armodafinil
armodafinil
ARMODAFINIL
Nuvigil

External Source Codes: 
CAS Registry Number 112111-43-0 (see NLM ChemIDplus info)
FDA UNII Code V63XWA605I
PDQ Closed Trial Search ID 617902
PDQ Open Trial Search ID 617902 (check for NCI PDQ open clinical trial info)
UMLS CUI C1701455

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Excessive sleepiness
Chemical_Formula C15H15NO2S
code C65241
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Armodafinil
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C65241

Mainbox Bottom